Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.5K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

2.7K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.7K
Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

1.1K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.1K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

223
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
223
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.7K
Chronic Obstructive Pulmonary Disease-V: Management01:29

Chronic Obstructive Pulmonary Disease-V: Management

2.5K
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantitative CT-Derived extrapulmonary body composition and the risk of acute exacerbations in COPD: A prospective cohort study.

Respiratory medicine·2026
Same author

COPD Patients with a High Exacerbation Risk: Baseline Data Analysis of a National Chinese Prospective Multi-Center Study of Quality Improvement Project.

International journal of chronic obstructive pulmonary disease·2026
Same author

Response.

Chest·2026
Same author

From winter flounder to multifunctional applications: A review of pleurocidin-like peptides via visualization and trend analysis.

Microbial pathogenesis·2026
Same author

Correlation between left atrium fractal dimension and cardiac function in patients with atrial fibrillation.

The British journal of radiology·2026
Same author

Ultrafine Nanoporous Ordered High-Entropy Intermetallics with Isolated Multisites toward Electrocatalytic Aldehyde Hydrogenation.

Journal of the American Chemical Society·2026

Related Experiment Video

Updated: May 25, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
08:05

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

14.0K

Quantitative CT and COPD: cluster analysis reveals five distinct subtypes with varying exacerbation risks.

Chusheng Peng1, Zizheng Chen1,2, Haobin Zhou1

  • 1Department of Clinical Medicine, Guangzhou Medical University, Guangzhou, 511436, China.

BMC Pulmonary Medicine
|February 26, 2025
PubMed
Summary

Researchers identified five distinct COPD subtypes using CT imaging and cluster analysis, revealing significant differences in exacerbation risk among these patient groups.

Keywords:
Chronic obstructive pulmonary diseaseCluster analysisDisease axesLongitudinal outcomes

More Related Videos

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
02:09

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Published on: April 12, 2024

519
Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD
04:03

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

Published on: September 27, 2024

571

Related Experiment Videos

Last Updated: May 25, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
08:05

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

14.0K
Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
02:09

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Published on: April 12, 2024

519
Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD
04:03

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

Published on: September 27, 2024

571

Area of Science:

  • Pulmonary Medicine
  • Radiology
  • Data Science

Background:

  • Chronic Obstructive Pulmonary Disease (COPD) heterogeneity is increasingly recognized.
  • Understanding COPD subtypes is crucial for personalized treatment strategies.
  • Quantitative CT imaging offers detailed insights into lung structure.

Purpose of the Study:

  • To characterize COPD heterogeneity using quantitative CT imaging.
  • To identify distinct COPD subtypes through principal component analysis (PCA) and cluster analysis.
  • To evaluate the clinical relevance of identified subtypes regarding acute exacerbation risk.

Main Methods:

  • Utilized data from 1879 participants in the SPIROMICS study.
  • Applied PCA and k-means clustering to quantitative CT parameters.
  • Validated cluster stability using normalized mutual information (NMI) across 10 sampling cycles.

Main Results:

  • Identified five COPD subtypes based on quantitative CT features:
  • 1. Male-dominated low disease impact
  • 2. Obesity with high symptom burden
  • 3. Airway wall lesions
  • 4. Upper lobe predominant emphysema
  • 5. Severe emphysema
  • Significant differences in acute exacerbation risk were observed among the five clusters.

Conclusions:

  • Cluster analysis successfully identified five distinct COPD subtypes based on quantitative CT.
  • These subtypes exhibit significant variations in baseline characteristics and acute exacerbation risk.
  • The identified clustering is stable and reproducible, supporting its potential clinical utility.