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Published on: August 21, 2017
Hydroxyurea-related ileocecal region ulcers as a rare complication: A case report
Wen-Jin Yuan1, Yi-Juan Zheng1, Bing-Rong Zhang1
1Department of Infection Disease, Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian province, Fujian Medical University Affiliated First Quanzhou Hospital, Quanzhou 362000, Fujian Province, China.
Background:
Hydroxyurea, an antimetabolite, is frequently prescribed for various hematological disorders, and its common side effects include gastrointestinal problems, cutaneous or mucosal lesions and pyrexia/fever.
Case Summary:
This study reports the case of a 67-year-old woman who developed recurrent abdominal pain after 10 years of continuous hydroxyurea therapy for primary thrombocythemia. Colonoscopy revealed an ileocecal ulcer. After discontinuing hydroxyurea therapy for 6 months, follow-up colonoscopy showed a significant reduction in the ulceration.
Conclusion:
We consider cecal ulcers as a rare complication of hydroxyurea therapy which typically resolves upon stopping the drug.
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