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Bioactive Inorganic Materials for Innervated Multi-Tissue Regeneration
Hongjian Zhang1, Ziyi Zhao1,2, Chengtie Wu1,2
1State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|February 27, 2025
Summary
Inorganic biomaterials show promise for tissue engineering by promoting both tissue and nerve regeneration. This review explores their use in repairing nerves and innervated tissues for improved functional recovery.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Tissue engineering seeks to restore damaged tissues, but functional recovery is hindered by inadequate innervation.
- Multifunctional biomaterials that induce both tissue and neural growth offer a promising solution.
Purpose of the Study:
- To provide a comprehensive overview of inorganic biomaterials for innervated multi-tissue regeneration.
- To highlight recent advancements and future perspectives in this field.
Main Methods:
- Review of classification, properties, and composite design of inorganic biomaterials.
- Systematic review of recent progress in regenerating nerve and nerve-innervated tissues using inorganic biomaterials.
Main Results:
- Inorganic biomaterials offer tunable properties and ease of combination with other materials for enhanced therapeutic effects.
- Significant progress has been made in using inorganic biomaterials for regenerating various nerves and nerve-innervated tissues, achieving functional recovery.
Conclusions:
- Inorganic biomaterials are crucial for advancing innervated multi-tissue regeneration.
- This field offers a novel strategy for tissue regeneration by integrating innervation, addressing current challenges and paving the way for future research.
