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Updated: May 25, 2025

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay
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Published on: March 10, 2020

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TANGO2 is an acyl-CoA binding protein.

Agustin Leonardo Lujan1, Ombretta Foresti1, Jose Wojnacki1

  • 1Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology , Barcelona, Spain.

The Journal of Cell Biology
|February 27, 2025
PubMed
Summary

TANGO2 protein loss causes metabolic crises. Our study shows TANGO2 binds acyl-CoA in mitochondria, and mutations disrupt this, offering new therapeutic targets for TANGO2-related diseases.

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