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Controversies in chronic histiocytic intervillositis

Virginie Collin-Bund1, Vincent Poindron2, Pauline Le Van Quyen3

  • 1Department of Gynecology and Obstetrics, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; Laboratoire d'ImmunoRhumatologie Moléculaire, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR_S 1109, Institut thématique interdisciplinaire (ITI) de Médecine de Précision de Strasbourg, Transplantex NG, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Strasbourg, France; Department of Maternal Fetal Medicine, Strasbourg University Hospital, Strasbourg, France.

Journal of Gynecology Obstetrics and Human Reproduction
|February 27, 2025
PubMed
Summary

Chronic histiocytic intervillositis (CHI) is a rare pregnancy complication involving maternal immune cells attacking the placenta. This review explores its causes, diagnosis, and management, highlighting severe fetal risks.

Keywords:
AlloimmunizationChronic histiocytic intervillositisHuman leucocyte antigenImmunomodulationSARS-COV-2

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