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Exploring the non-linear association and threshold effect of sedentary behavior on testosterone deficiency
Liangchun Cai1, Haiping Xie2, Wue Li3,4
1Department of Endocrinology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China. cailiangchunfj@163.com.
Endocrine
|February 27, 2025
Summary
Prolonged sedentary behavior is linked to an increased risk of testosterone deficiency (TD) in adult men. This association becomes more pronounced with sedentary time exceeding 4.5 hours daily.
Area of Science:
- Endocrinology
- Public Health
- Men's Health
Background:
- Sedentary behavior is a growing public health concern.
- Its link to hormonal imbalances, such as testosterone deficiency (TD), requires further investigation.
- Understanding this association is crucial for preventative health strategies.
Purpose of the Study:
- To investigate the association between sedentary time and testosterone deficiency in adult males.
- To explore potential non-linear relationships and thresholds in this association.
- To identify specific populations at higher risk.
Main Methods:
- Cross-sectional analysis of 6057 adult males from NHANES 2011-2016.
- Sedentary time categorized into quartiles; TD defined as serum testosterone < 300 ng/dL.
- Logistic regression, restricted cubic splines, and subgroup analyses were performed.
Main Results:
- A significant positive association was found between sedentary time and TD.
- Non-linear relationship observed, with increased TD risk beyond 4.5 hours of sedentary time daily.
- Association was strongest in Non-Hispanic Whites, smokers, and drinkers; weaker in individuals with diabetes.
Conclusions:
- Prolonged sedentary behavior is significantly associated with a higher risk of testosterone deficiency.
- Sedentary behavior may be a key factor in the development of TD, especially in at-risk groups.
- Findings highlight the importance of reducing sedentary time for men's hormonal health.
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