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[Effect of Temperature Cycle Preservation on Platelet Aggregation Rate and Routine Parameters]
Ju-Ling Liang1, Zhi-Hao Deng1, Chuang-Jin Zhuo1
1Foshan Central Blood Station, Foshan 528000, Guangdong Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi
|February 28, 2025
Summary
Platelet aggregation function and routine parameters change during temperature cycling preservation, falling between 4°C and 22°C storage. This study provides data for optimizing platelet preservation methods.
Area of Science:
- Hematology
- Transfusion Medicine
- Biopreservation
Context:
- Platelet preservation is critical for transfusion efficacy.
- Current methods like cold storage at 4°C have limitations.
- Exploring alternative preservation techniques is essential.
Purpose:
- To compare platelet aggregation rate and routine parameters under different storage conditions: temperature cycling, 4°C cold storage, and 22°C oscillating storage.
- To provide experimental data to inform optimal platelet preservation strategies.
Summary:
- Platelet maximum aggregation rate (MAR) decreased over time in all tested conditions, with the fastest decline at 22°C and slowest at 4°C.
- Temperature cycling preservation showed intermediate changes in MAR and routine parameters (platelet count, MPV, PDW, P-LCR) compared to 4°C and 22°C.
- Routine parameters like MPV and P-LCR increased in temperature cycling and 22°C groups, while decreasing in the 4°C group.
Impact:
- Findings suggest temperature cycling preservation offers an intermediate option between standard cold storage and room temperature oscillation.
- This research contributes valuable data for developing improved platelet storage protocols.
- Understanding these parameter changes can help maintain platelet viability and function for longer periods.
