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Updated: May 25, 2025

The Synergistic Effect of Visible Light and Gentamycin on Pseudomona aeruginosa Microorganisms
Published on: July 2, 2013
Amphiphilic lysine-based glycopeptides exert antibacterial effects on Pseudomonas aeruginosa
Shan-Shan Su1, Chao-Na An1, Gao-Juan Lin1
1College of Chemistry and Materials Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education), State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, Baoding, 071002, China. lixl@hbu.edu.cn.
Abstract:
The development of new antibiotics with novel antimicrobial mechanisms and strategies has attracted considerable interest. Herein, three amphiphilic lysine-based glycopeptides (SA-l-Gal, OA-l-Gal and LOA-l-Gal) were developed, and their antibacterial activity and inhibition effects on biofilm formation on P. aeruginosa were studied. SA-l-Gal with a stearic acid group modification exhibited better antibacterial effects than the other lysine-based glycopeptides by damaging the bacterial membrane. Furthermore, SA-l-Gal could effectively reduce inflammation factor expression, enhance the formation of new blood vessels, and promote the healing of P. aeruginosa-infected mouse wounds. This result provides insights into the development of glycomimetic drugs against P. aeruginosa infection.
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