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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
Published on: September 14, 2010
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KSHVbook: An Information-Sharing Database for Kaposi's Sarcoma-Associated Herpesvirus
Yong Jiang1,2, Danping Niu2, Lei Yu1,2
1Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.
Journal of Medical Virology
|February 28, 2025
Summary
KSHVbook is a new database providing comprehensive KSHV information and analysis tools. This resource aims to accelerate Kaposi's sarcoma-associated herpesvirus (KSHV) research by integrating data and offering specialized analytical functions.
Area of Science:
- Virology
- Bioinformatics
- Genomics
Background:
- Kaposi's sarcoma-associated herpesvirus (KSHV) is linked to several diseases, including Kaposi's sarcoma (KS).
- Existing KSHV research platforms lack comprehensive data and tailored analysis tools.
Purpose of the Study:
- To develop KSHVbook, a specialized database and analysis platform for KSHV research.
- To consolidate KSHV genetic, protein, and regulatory information.
Main Methods:
- Development of a web-based database (KSHVbook) integrating diverse KSHV data.
- Inclusion of extensive information on genes, proteins, transcription factor binding sites (TFBSs), and miRNA-host interactions.
- Implementation of analytical tools for viral genome regions, TFBSs, and miRNA targets.
Main Results:
- KSHVbook provides access to ~35,010 TFBSs and ~342,010 KSHV miRNA-host target gene relationships.
- Predicted protein structures using AlphaFold3 and qPCR primers are available.
- Analytical tools facilitate the discovery of regulatory relationships between host factors and viral genes.
Conclusions:
- KSHVbook serves as a centralized, integrated data resource for KSHV research.
- The platform simplifies data acquisition and offers accessible analysis tools.
- KSHVbook is continuously updated to include new features and data.
