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Matrix-driven translocation of cells and nonliving particles
Science (New York, N.Y.)
|May 17, 1985
Summary
Cells can move towards fibronectin-rich areas within complex extracellular matrices. This biophysical process, driven by matrix formation, influences cell migration in development and tissue repair.
Area of Science:
- Biophysics
- Cell Biology
- Biomaterials Science
Background:
- Metazoan cells create intricate extracellular matrices (ECM).
- ECM composition, including collagen and fibronectin, influences cellular behavior.
Purpose of the Study:
- To investigate cell and particle translocation within engineered ECMs.
- To determine the driving forces behind this movement.
Main Methods:
- In vitro assembly of nonuniform collagen-fibronectin matrices.
- Observation of cell and polystyrene-latex bead movement.
Main Results:
- Cells and beads translocated from fibronectin-poor to fibronectin-rich matrix regions.
- Translocation was independent of diffusion, convection, and electrostatic effects.
- Non-equilibrium phenomena at matrix interfaces may drive movement.
Conclusions:
- ECM formation alone can drive cell and particle translocation.
- This biophysical process is a potential mechanism for cell migration in embryogenesis, inflammation, wound healing, and tumor invasion.