Related Experiment Video
Updated: Aug 15, 2026
15:40
Forward Genetic Approach to Uncover Stress Resistance Genes in Mice — A High-throughput Screen in ES Cells
Published on: November 11, 2015
Evolution in inbred strains of mice appears rapid
Science (New York, N.Y.)
|June 7, 1985
Summary
Genetic variation in common mouse strains exceeds expectations, challenging current assumptions. Researchers suggest early selection for heterozygosity or gene conversion as potential explanations for this observed diversity.
Area of Science:
- Genetics
- Animal Models
- Evolutionary Biology
Background:
- Inbred mouse strains are crucial for genetic research.
- Understanding genetic variation within these strains is essential for experimental reproducibility.
Purpose of the Study:
- To investigate the extent of genetic variation in ten commonly used inbred mouse strains.
- To evaluate current assumptions regarding genetic diversity in these models.
- To explore potential explanations for observed genetic discrepancies.
Main Methods:
- Analysis of genetic variation across 97 specific loci.
- Comparison of observed variation against expected levels based on current genetic models.
Main Results:
- Observed genetic variation significantly exceeds levels predicted by current assumptions.
- Readily apparent explanations for this excess variation were investigated and found lacking.
- The study suggests novel mechanisms, such as early selection for heterozygosity or gene conversion, as potential causes.
Conclusions:
- Current models may not fully account for the genetic diversity in commonly used inbred mouse strains.
- Further research into mechanisms like selection for heterozygosity or gene conversion is warranted.
- The estimated common ancestor of these strains lived approximately 150 years ago, providing a timeframe for observed genetic divergence.
Related Concept Videos
01:16In-vitro Mutagenesis
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
01:24Evolution of New Traits in Microbes
Microorganisms evolve rapidly due to their large population sizes and short generation times, often exhibiting measurable changes within days under laboratory conditions. Natural selection acts on standing genetic variation, enabling the retention and amplification of beneficial traits that confer fitness advantages in changing environments.Adaptive Pigment Regulation in RhodobacterIn Rhodobacter, a genus of purple non-sulfur bacteria, light-harvesting pigments such as bacteriochlorophyll and...