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Updated: May 24, 2025

Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques
Published on: March 8, 2024
Investigation into the presence of alkaloids in Areca catechu-based single-use food-contact articles (FCA)
J Brad Mangrum1, Lowri DeJager1, Tim Begley1
1Human Foods Program, U.S. Food and Drug Administration, College Park, MD, USA.
Abstract:
In this work, we have developed a method to investigate the presence of four alkaloids and their migration potential from single-use, biodegradable Areca catechu-derived dinnerware. The seeds of Areca catechu palm, commonly referred to as the betel nut, are known to contain high concentrations of four alkaloids: arecoline, guvacoline, areciadine, and guvacine. Migration of these alkaloids into a food simulant was determined using a single-sided migration cell. The results indicate that carboxylic acid alkaloids, arecaidine, and guvacine, preferentially migrate under the experimental conditions which mimic the conditions of use for dinnerware.

