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Related Experiment Video

Updated: Jul 13, 2026

Reliable and High Efficiency Extraction of Kidney Immune Cells

Reliable and High Efficiency Extraction of Kidney Immune Cells

Published on: August 19, 2016

Seraph 100 Microbind Affinity Blood Filter for Persistent Pediatric BK Virus Nephropathy.

Meredith Harris^1,2, Mahima Keswani^1,2, Theresa Mottes^1,2

¹Ann & Robert Lurie Childrens Hospital of Chicago, Chicago, Illinois, USA.

Pediatric Transplantation

|February 28, 2025

Summary

The Seraph 100 filter successfully cleared BK viremia in a kidney transplant candidate, demonstrating a potential new therapy for BK viral infections, especially in patients with end-stage kidney disease.

Keywords:

end‐stage renal disease heart transplant immunoadsorpsion kidney transplantation viral infection

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Published on: May 20, 2021

Area of Science:

Nephrology
Virology
Transplantation Immunology

Background:

BK viremia is a significant barrier to kidney transplantation, with limited effective therapies.
Current management often involves immunosuppression reduction, which can be insufficient.
The Seraph 100 filter utilizes heparin sulfate proteoglycans to bind pathogens, mimicking natural glycocalyx function.

Observation:

A 14-year-old patient with a history of cardiac transplant developed BK nephropathy and end-stage kidney disease (ESKD).
Despite 4 years of medical management and immunosuppression reduction, BK viral replication persisted.
The Seraph 100 Microbind Affinity Blood Filter was used extracorporeally with continuous renal replacement therapy (CRRT) for 48 hours.

Findings:

BK viral titers, after an initial slight increase, cleared within two months post-treatment.
The patient successfully underwent kidney transplantation without BK viremia recurrence.
No adverse events were noted, apart from transient emesis at CRRT initiation.

Implications:

This case presents proof of concept for the Seraph 100 filter's efficacy in clearing BK viremia.
The Seraph 100 may offer a viable therapeutic option for ESKD patients with existing dialysis access.
Further studies are warranted to explore the Seraph 100 as a treatment for BK viral infections.