Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Design Consideration01:22

Design Consideration

177
Designing a structure involves a series of considerations, primarily the material's ultimate strength, calculated through tests that measure changes under increased force until the material reaches its breaking point or limit. The ultimate load, where the material breaks, is divided by its original cross-sectional area, resulting in the ultimate normal stress or strength. The ultimate shearing stress is another significant factor taken into account.
The factor of safety is another key...
177
Cleaning, Sterilization, and Disinfection01:30

Cleaning, Sterilization, and Disinfection

6.6K
Cleaning, disinfection, and sterilization are the methods that help to break the infection chain and prevent disease.
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...
6.6K
Critical Thinking II01:25

Critical Thinking II

2.7K
Critical thinking is a cognitive process with several attributes. The attributes of critical thinking include the following:
2.7K
Methods of Documentation V: CBE01:23

Methods of Documentation V: CBE

870
Charting by Exception, or CBE, is a method of documentation used in healthcare, particularly in nursing, that focuses on documenting only significant or abnormal findings rather than recording every detail. This approach aims to streamline the documentation process, improve efficiency, and ensure that healthcare providers can quickly identify deviations from normalcy in patient assessments.
In CBE, healthcare professionals establish predefined standards of practice that define what constitutes...
870
Design Example: Managing Concrete Workability01:14

Design Example: Managing Concrete Workability

67
This example deals with managing the workability of concrete for a raft foundation project under hot weather conditions. Workability is crucial for ensuring the concrete is easy to place, compact, and finish. In this scenario, a slump test — a common method to measure the workability of fresh concrete — initially indicated low workability. This was attributed to the rapid water loss from the concrete mix, exacerbated by the high temperatures causing the course aggregates to heat up.
67
Guidelines for Writing Outcome01:11

Guidelines for Writing Outcome

2.6K
When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Translational assessment instruments for preclinical to first-in-human decision-making: a scoping review.

Journal of translational medicine·2026
Same author

Evaluating the translational value of preclinical models: Available tools and frameworks, challenges and strategies.

Alternatives to laboratory animals : ATLA·2025
Same author

Author Guide for Addressing Animal Methods Bias in Publishing.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2023
Same author

Proceedings of a workshop to address animal methods bias in scientific publishing.

ALTEX·2022
Same author

FRAME 50th Anniversary Symposium, July 2019.

Alternatives to laboratory animals : ATLA·2019

Related Experiment Video

Updated: May 24, 2025

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative
07:59

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative

Published on: August 21, 2021

5.3K

Reviewing Current Guidance for the 'R' of Replacement and Rethinking it with the 'Replacement Checklist'.

Juliet P Dukes1, Amy Beale1, Celean Camp1

  • 1Replacing Animal Research, Nottingham, UK.

Alternatives to Laboratory Animals : ATLA
|March 1, 2025
PubMed
Summary

Researchers can improve the identification and assessment of animal replacement methods in experiments. A new checklist and process improvements aim to overcome barriers to adopting these alternative approaches.

Keywords:
3RsNAMsNATsalternativesanimal researchchecklistreplacement

More Related Videos

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

3.8K
Author Spotlight: Recent Advancements in Reoperative Foregut Surgery
04:14

Author Spotlight: Recent Advancements in Reoperative Foregut Surgery

Published on: September 22, 2023

413

Related Experiment Videos

Last Updated: May 24, 2025

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative
07:59

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative

Published on: August 21, 2021

5.3K
A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

3.8K
Author Spotlight: Recent Advancements in Reoperative Foregut Surgery
04:14

Author Spotlight: Recent Advancements in Reoperative Foregut Surgery

Published on: September 22, 2023

413

Area of Science:

  • Animal research ethics
  • Toxicology and pharmacology
  • Biomedical research

Background:

  • The Three Rs principles (replacement, reduction, refinement) guide animal research.
  • Legislation mandates the use of animal replacement alternatives when scientifically feasible.
  • Current guidance for identifying replacement methods is often unclear, hindering adoption.

Purpose of the Study:

  • To propose improvements for identifying and assessing animal replacement alternatives.
  • To develop a practical checklist to aid researchers in this process.
  • To support ethical review bodies and journal editors in evaluating the use of alternatives.

Main Methods:

  • Review of existing guidance and barriers to implementing animal replacement.
  • Development of a practical checklist for assessing replacement approaches.
  • Proposal of simple improvements to current research processes.

Main Results:

  • Identified confusion and barriers in current methods for finding replacement techniques.
  • Proposed a structured approach with a checklist to facilitate the assessment of alternatives.
  • Aimed to increase researcher confidence and compliance with replacement principles.

Conclusions:

  • Simple process improvements and a practical checklist can enhance the identification and assessment of animal replacement alternatives.
  • The proposed tools can support researchers, funding bodies, and ethical review committees.
  • Addressing barriers is crucial for the effective implementation of the principle of replacement in scientific research.