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Therapeutic Targeting of PARP Expression and Glycolysis Rate-Limiting Enzymes in Breast Cancer Patients

Shams Firas Adnan¹, Zainab N Najim Al-Abady¹

¹Department of Chemistry, Faculty of Sciences, University of Al-Qadisiyah, Iraq.

Asian Pacific Journal of Cancer Prevention : APJCP

|March 1, 2025

Abstract

Background:

Breast cancer is a heterogeneous disease characterized by diverse biochemical, histological, and clinical features. PARP1 and glycolysis rate-limiting enzymes play critical roles in cancer progression, making them promising therapeutic targets.

Aim:

This study aimed to evaluate the expression levels of PARP1 and key glycolytic enzymes (HK, PFK, and PK) in breast cancer patients and assess their potential as therapeutic indicators.

Materials And Methods:

A total of 120 participants (60 breast cancer patients and 60 healthy controls) were included in the study. Blood samples were collected to measure PARP1 expression and the levels of glycolytic enzymes using ELISA. Statistical analyses were performed to compare the two groups.

Results:

PARP1 expression and glycolytic enzyme levels (HK, PFK, and PK) were significantly higher in breast cancer patients compared to healthy controls (p < 0.0001).

Conclusion:

The overexpression of PARP1 and key glycolytic enzymes indicates their involvement in breast cancer progression and underscores their potential as therapeutic targets and biomarkers.

Keywords:

Breast cancer (BC)PARP1 hexokinase phosphofructokinase pyruvate kinase

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