Lycopene: A potent antioxidant to alleviate kidney disease

Kidney disease is a major public health problem worldwide and one of the common causes of death in patients. How to effectively treat or alleviate renal diseases has not only attracted the attention of a large number of scholars, but is likewise a great challenge. Oxidative stress is the main mechanism leading to kidney injury. Natural antioxidant substances not only have efficient antioxidant capacity, but also have the advantage of high safety and low side effects. Lycopene is a naturally occurring carotenoid found mainly in tomatoes or tomato products. Epidemiologic investigations have shown that lycopene has potent antioxidant properties, scavenges reactive substances, and has a protective role in kidney disease. This paper summarizes the biochemical properties and antioxidant mechanisms of lycopene in the context of animal experiments and clinical studies of lycopene in renal diseases. We found that lycopene exerts its protective effects against kidney injury mainly through anti-oxidative stress and anti-inflammatory effects. Meanwhile, lycopene has been found to reduce the incidence of Chronic Kidney Disease (CKD) as well as mortality in some CKD patients. In addition to this, lycopene intake is negatively correlated with the incidence of kidney cancer and also mitigates the nephrotoxic damage of cisplatin. Therefore, lycopene has a promising application in the treatment of kidney diseases. However, there are relatively few clinical studies on lycopene in renal diseases, and subsequent research studies in large-scale populations are still needed to determine the value of lycopene in renal diseases even further.