Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Cell Death01:30

Overview of Cell Death

7.1K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
7.1K
Apoptosis01:30

Apoptosis

11.2K
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
11.2K
Autophagic Cell Death01:18

Autophagic Cell Death

3.4K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
3.4K
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

6.3K
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
6.3K
Regulated Protein Degradation02:58

Regulated Protein Degradation

7.2K
It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
7.2K
The Cell Cycle Control System01:28

The Cell Cycle Control System

2.7K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Operative time and recurrence across five techniques of inguinal hernia repair: a Bayesian network meta-analysis of 29 randomized trials.

Hernia : the journal of hernias and abdominal wall surgery·2026
Same author

Anti-PD-1 blockade reverses low-intensity electric stimulation-driven pancreatic cancer progression.

Frontiers in immunology·2026
Same author

Targeting UXS1-Dependent Glucuronate Detoxification Potentiates Metformin's Anti-Tumor Efficacy in Lung Adenocarcinoma.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Cytokines and cancer-associated fibroblasts.

Journal of hematology & oncology·2026
Same author

Cone-beam CT-guided thermal ablation vs video-assisted thoracic surgery in treatment of non-small-cell lung cancer: A propensity score matching analysis.

Journal of cancer research and therapeutics·2026
Same author

Kidney neural diversity and blood pressure regulation: resolving controversies and guiding hypertension therapy.

Kidney international·2026

Related Experiment Video

Updated: Jun 12, 2025

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
06:12

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum

Published on: May 3, 2024

1.7K

Lactylation and regulated cell death.

Wenlong Zhang1, Guangyao Shan1, Guoshu Bi1

  • 1Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai 200032, China.

Biochimica Et Biophysica Acta. Molecular Cell Research
|March 1, 2025
PubMed
Summary
This summary is machine-generated.

Lactylation, a new protein modification, regulates cell death by altering gene expression and cellular processes. This review explores lactylation's role in regulated cell death (RCD) and future research directions.

Keywords:
ApoptosisAutophagyFerroptosisLactylationPyroptosis

More Related Videos

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

8.6K
Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells
12:44

Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells

Published on: October 11, 2012

23.3K

Related Experiment Videos

Last Updated: Jun 12, 2025

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
06:12

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum

Published on: May 3, 2024

1.7K
Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

8.6K
Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells
12:44

Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells

Published on: October 11, 2012

23.3K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Lactylation is a recently discovered post-translational modification involving the addition of lactate to lysine residues.
  • This modification impacts various cellular mechanisms, particularly those involved in regulated cell death (RCD).
  • Lactylation occurs in two main forms: histone lactylation and non-histone lactylation.

Purpose of the Study:

  • To provide a comprehensive overview of recent advancements in understanding lactylation's role in RCD.
  • To explore the distinct roles of histone and non-histone lactylation in cellular fate.
  • To identify potential future research directions in the field of lactylation and RCD.

Main Methods:

  • This review synthesizes recent research findings on lactylation.
  • It examines the mechanisms by which lactylation influences gene transcription and cellular pathways.
  • The review discusses the impact of lactylation on various RCD-related processes.

Main Results:

  • Histone lactylation regulates RCD by modulating the transcription of cell death-related genes.
  • Non-histone lactylation affects RCD by targeting enzymes, transcription, cell cycle, death pathways, and metabolism.
  • Lactylation is a significant modulator of cellular fate determination.

Conclusions:

  • Lactylation is a critical post-translational modification that profoundly influences regulated cell death.
  • Understanding lactylation's mechanisms offers new insights into cellular survival and death.
  • Further research into lactylation is essential for a deeper comprehension of cellular fate.