Emerging 3D printing technologies for solid oral dosage forms: Processes, materials and analytical tools for...

Area of Science:

• Pharmaceutical Sciences
• Manufacturing Technology

Background:

• Three-dimensional (3D) printing enables personalized drug delivery and manufacturing flexibility.
• Layer-by-layer material deposition allows tailored solid oral dosage forms and modified drug release profiles.
• Quality assurance remains a challenge in monitoring and controlling critical 3D printing steps.

Purpose of the Study:

• To review advances in 3D printing for solid oral dosage forms.
• To emphasize critical process parameters and material attributes for optimizing printing.
• To explore real-time analytical tools for quality assurance in pharmaceutical additive manufacturing.

Main Methods:

• Literature review of recent advances in 3D printing technologies for pharmaceuticals.
• Analysis of critical process parameters and material attributes impacting tablet performance.
• Discussion of real-time analytical tools and quality assurance considerations.

Main Results:

• 3D printing allows for precise control over tablet geometry and drug release.
• Understanding material attributes and process parameters is key to optimizing 3D printing.
• Real-time monitoring is crucial for ensuring the quality of 3D-printed drug products.

Conclusions:

• 3D printing holds significant potential for personalized pharmaceutical manufacturing.
• Quality assurance is paramount throughout the additive manufacturing process for drug products.
• Further research into process control and material science is needed to fully realize 3D printing's potential in pharmaceuticals.