Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correlated gene copy number changes in a seminal fluid protein network in <i>Drosophila</i>.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

The Stellate meiotic drive system of Drosophila melanogaster is active in contemporary populations.

Genetics·2026

Same author

A New Lifeline: Feasibility and Outcomes of Altruistic Donor Programs in Living-Donor Liver Transplantation, A Single Saudi Center Experience.

Annals of transplantation·2026

Same author

e3SIM: Epidemiological-ecological-evolutionary simulation framework for genomic epidemiology.

Methods in ecology and evolution·2026

Same author

A genetic association study of iron absorption in adults of East Asian or Northern European ancestry from the Iron Genes in East Asian and Northern European Adults Study (FeGenes).

The American journal of clinical nutrition·2026

Same author

Biopharmaceutical assessment of naloxone permeation through human respiratory epithelial tissues: A chromatographic-mass spectrometric approach with cloud based aerosol dosing and delivery.

Journal of pharmaceutical and biomedical analysis·2026

Same journal

Approaches for enhancing bioavailability of macromolecular drugs.

International journal of pharmaceutics·2026

Same journal

Characteristics of asymmetric microcrystalline solidification pellets and a better prediction for bioequiavailability based on solubility-permeability theory.

International journal of pharmaceutics·2026

Same journal

A CFPD-FSI analysis of the impact of nasal hairs on airflow patterns, nasal resistance, and particle filtration in a realistic human nasal airway.

International journal of pharmaceutics·2026

Same journal

Transient hydrate formation during disintegration of film-coated pharmaceutical tablets.

International journal of pharmaceutics·2026

Same journal

Erratum to "In vitro - In vivo correlation modeling of an oxcarbezapine extended-release formulation using numerical deconvolution" [Int. J. Pharm. 699 (2026) 126952].

International journal of pharmaceutics·2026

Same journal

Use of a hydrophilic excipient to modulate the release of dapivirine, copper ions and zinc ions from a matrix-type vaginal ring.

International journal of pharmaceutics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 3, 2026

Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole

Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole

Published on: December 5, 2025

Technical challenges and quality considerations for dissolving microneedles.

Nahid S Kamal¹, Samuel Acheampong¹, Rokon Uz Zaman¹

¹Office of Pharmaceutical Quality Research, Office of Pharmaceutical Quality (OPQ), CDER, FDA, USA.

International Journal of Pharmaceutics

|April 1, 2026

Summary

This summary is machine-generated.

Optimizing polyvinyl alcohol (PVA) concentration in dissolving microneedles (DMNs) enhances structural integrity and controls drug release. The polymer-to-API ratio impacts drug distribution and release kinetics for improved transdermal delivery systems.

Keywords:

Artificial intelligence assisted image analysis Dissolving microneedles In vitro drug permeation In vitro drug release Mechanical properties Microneedle disintegration Microneedles

More Related Videos

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

Polymeric Microneedle Array Fabrication by Photolithography

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

Related Experiment Videos

Last Updated: Apr 3, 2026

Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole

Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole

Published on: December 5, 2025

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

Polymeric Microneedle Array Fabrication by Photolithography

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

Area of Science:

Pharmaceutical Sciences
Biomaterials Engineering
Drug Delivery Systems

Background:

Dissolving microneedles (DMNs) offer transdermal drug delivery by penetrating the stratum corneum.
Challenges exist in optimizing DMN formulations for mechanical properties and drug release.
Lack of standardized quality control hinders DMN product development.

Purpose of the Study:

To investigate testing methods for DMNs.
To evaluate the impact of polymer-to-API ratio on DMN critical quality attributes (CQAs).
To understand how CQAs influence drug release and skin permeation.

Main Methods:

DMNs formulated with varying polyvinyl alcohol (PVA) concentrations and metoprolol succinate.
Microscopic imaging with AI segmentation for morphological analysis.
Intensity-distance analysis for drug distribution assessment.
Mechanical testing (fracture force) and in vitro drug release/permeation studies.

Main Results:

Pyramidal DMNs with consistent dimensions were successfully fabricated.
Increased PVA content enhanced microneedle fracture force and structural integrity.
Polymer-to-API ratio did not affect skin insertion or disintegration.
Higher PVA content slowed drug release, identifying polymer as a key release controller.
Drug permeation correlated with spatial drug distribution within the microneedles.

Conclusions:

Optimizing the PVA-to-drug ratio is crucial for controlling DMN drug release and permeation.
Controlling drug distribution within DMNs is essential for enhancing transdermal delivery performance.
Standardized testing methods are needed to address quality control challenges in DMN development.