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Updated: May 24, 2025

Author Spotlight: Recreating Melanoma Complexity with Patient-Derived Organoids for Immunotherapy Evaluation
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Author Spotlight: Recreating Melanoma Complexity with Patient-Derived Organoids for Immunotherapy Evaluation

Published on: September 6, 2024

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Decoding melanoma's cellular mosaic to unlock immunotherapy potential

Joanna Pozniak1, Jean-Christophe Marine1

  • 1Laboratory for Molecular Cancer Biology, VIB Center for Cancer Biology, KU Leuven, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium.

Trends in Cell Biology
|March 1, 2025
PubMed

Insights

Single-cell multiomics reveals the complex mosaic of cutaneous melanoma, improving understanding of cancer evolution and immunotherapy resistance. These advanced technologies are transforming cancer diagnosis and treatment strategies.

Area of Science:

  • Oncology
  • Genomics
  • Immunology

Background:

  • Cancer evolution is complex, influenced by intra-tumor heterogeneity from genetic mutations, epigenetics, immune infiltration, and microenvironment.
  • Identifying reliable cancer biomarkers and therapeutic targets is challenging due to this heterogeneity.
  • Understanding cellular machinery and tissue architecture is key to cancer progression.

Purpose of the Study:

  • To review how single-cell multiomics advances our understanding of cutaneous melanoma biology.
  • To explore the mechanisms of immunotherapy resistance in cutaneous melanoma.
  • To highlight the transformative potential of multiomic technologies in cancer research.

Main Methods:

  • Single-cell sequencing technologies.
  • Spatial multiomics approaches.
  • Review of current literature on cutaneous melanoma and immunotherapy.

Main Results:

  • Single-cell multiomics provides unprecedented insights into the cellular and molecular landscape of cutaneous melanoma.
  • These technologies illuminate the intricate interactions driving cancer progression and heterogeneity.
  • Crucial information regarding mechanisms of resistance to immunotherapy has been uncovered.

Conclusions:

  • Single-cell multiomics is revolutionizing the study of cancer, akin to restoring ancient mosaics.
  • Unraveling the cancer mosaic will transform diagnosis and treatment strategies.
  • These advancements offer new hope for overcoming immunotherapy resistance in melanoma.
Keywords:
immunotherapyintra-tumor heterogeneitymelanomasingle-cell multi-omics

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