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Related Experiment Video

Updated: May 24, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Identifying risk factors for postpartum depression in Mashhad, Iran, 2017-2024: a population-based case-control

Amin Moradi1, Mehdi Norouzi2, Ehsan Mosa Farkhani3,4

  • 1Department of Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.

Archives of Public Health = Archives Belges De Sante Publique
|March 2, 2025
PubMed
Summary

Postpartum depression (PPD) affects many mothers. This study found psychological factors like anxiety and depression history, alongside factors like younger maternal age and cesarean delivery, significantly increase PPD risk.

Keywords:
Postpartum depressionPsychological distressRisk factors

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Area of Science:

  • Reproductive Health
  • Maternal Mental Health
  • Epidemiology

Background:

  • Postpartum depression (PPD) is a prevalent and serious condition impacting women globally.
  • Identifying risk factors is crucial for effective prevention and management strategies.

Purpose of the Study:

  • To determine the frequency of postpartum depression (PPD) in Mashhad, Iran.
  • To identify significant risk factors associated with PPD in this population.

Main Methods:

  • A population-based case-control study utilizing data from the Sina Health Information System (SINAEHR).
  • The Edinburgh Postpartum Depression Scale (EPDS) was employed to classify cases (score > 12) and controls (score ≤ 12).
  • Bivariate and multivariate logistic regression analyses were conducted to ascertain risk factors.

Main Results:

  • Out of 108,952 women, 3.03% (3,407) were diagnosed with PPD.
  • Key risk factors identified include younger maternal age (≤20 years), history of abortion, cesarean delivery, preterm birth, twin births, and drug use.
  • Strong associations were found with psychological factors: history of anxiety, domestic violence, history of depression, and psychological distress.

Conclusions:

  • Psychological factors emerged as the most significant predictors of PPD.
  • Findings underscore the necessity of integrating mental health screenings and targeted support for high-risk women during pregnancy and postpartum.