Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obesity01:24

Obesity

358
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
358
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

418
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
418
Brain Imaging01:14

Brain Imaging

202
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
202
Neural Regulation01:37

Neural Regulation

39.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Compression of functional gradients during early nonrapid eye movement sleep.

PNAS nexus·2026
Same author

Adiposity and inflammation mediate altered metabolic profile in individuals with opioid use disorder.

Journal of psychiatric research·2026
Same author

Adiposity and inflammation mediate altered metabolic profiles in individuals with opioid use disorder.

medRxiv : the preprint server for health sciences·2026
Same author

Multimodal brain imaging-based classification of functional constipation subtypes using machine learning.

Journal of affective disorders·2026
Same author

Methylphenidate reorganizes cortical hierarchy through dopaminergic modulation.

Nature communications·2025
Same author

A viral Cyclin D homolog protein hijacks the metabolic stress sensor SESN2 to promote primary effusion lymphoma growth.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same journal

DXA-Measured Visceral Adipose Tissue and Accelerated Biological Aging in Middle-Aged Adults.

Obesity (Silver Spring, Md.)·2026
Same journal

Real-World Effectiveness of Semaglutide and Tirzepatide Compared With Bariatric Surgery.

Obesity (Silver Spring, Md.)·2026
Same journal

Prospective Association Between Weight Variability and Subsequent Long-Term Weight Loss in the CALERIE Study.

Obesity (Silver Spring, Md.)·2026
Same journal

Dietary Protein Reduction During Isocaloric Conditions Reduces Body Weight in Men With Overweight or Obesity.

Obesity (Silver Spring, Md.)·2026
Same journal

Six- and Twelve-Month Changes in Body Composition and 24-h Energy Expenditure After a Very Low-Calorie Ketogenic Diet.

Obesity (Silver Spring, Md.)·2026
Same journal

SURMOUNT-REAL UK: A Pragmatic Randomized Clinical Trial to Assess the Effectiveness of Tirzepatide in Adults With Obesity.

Obesity (Silver Spring, Md.)·2026
See all related articles

Related Experiment Video

Updated: May 24, 2025

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
09:06

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

12.1K

Obesity is associated with progressive brain structural changes.

Huiling Zhou1,2, Yang Hu1,2, Guanya Li1,2

  • 1Center for Brain Imaging, School of Life Science and Technology, Xidian University & Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, Xi'an, China.

Obesity (Silver Spring, Md.)
|March 3, 2025
PubMed
Summary
This summary is machine-generated.

Obesity progression is linked to gray matter volume reductions in brain regions associated with reward and inhibitory control. These structural brain changes offer new insights for obesity treatment.

More Related Videos

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

15.6K
Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

13.9K

Related Experiment Videos

Last Updated: May 24, 2025

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
09:06

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

12.1K
Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

15.6K
Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

13.9K

Area of Science:

  • Neuroscience
  • Radiology
  • Public Health

Background:

  • Obesity is a growing global health concern.
  • Brain structural alterations may underlie obesity-related behaviors.
  • Understanding these changes is crucial for effective interventions.

Purpose of the Study:

  • To investigate the relationship between obesity progression and brain structural changes.
  • To identify specific brain regions affected by increasing Body Mass Index (BMI).

Main Methods:

  • Magnetic resonance imaging (MRI) was used to analyze brain structure.
  • 258 participants with overweight or obesity and 74 normal-weight controls were included.
  • Causal structural covariance networks were employed to examine progressive impacts.

Main Results:

  • Gray matter volume reductions were observed with increasing BMI, originating in the caudate nucleus, orbitofrontal cortex, and insula.
  • These changes progressed to the hippocampus, parahippocampal gyrus, precuneus, and dorsolateral prefrontal cortex.
  • The caudate nucleus and medial orbitofrontal cortex showed causal influence on other affected brain regions.

Conclusions:

  • Brain gray matter changes in obesity may start in reward processing areas and spread to regions involved in control and memory.
  • These findings provide a novel perspective for clinical interventions targeting obesity.