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Published on: December 19, 2020
Candida-Associated Renal Papillary Necrosis Following Severe COVID-19 Infection
Ranjani Ravi1, Aravind Reghukumar2, Vimala A1
1Nephrology Cosmopolitan Hospital, Thiruvananthapuram, Kerala, India.
Journal of Brown Hospital Medicine
|March 3, 2025
Summary
Candida-associated renal papillary necrosis is a rare kidney complication. This study highlights its occurrence in patients with recent severe COVID-19 and immunosuppression, suggesting a link to immune system changes.
Area of Science:
- Nephrology
- Infectious Diseases
- Immunology
Background:
- Candida-associated renal papillary necrosis is a rare condition, typically seen in immunocompromised individuals with candidemia.
- Previous literature on this condition is limited, with few documented cases.
Observation:
- Two patients presented with hydroureteronephrosis and were diagnosed with candida-associated renal papillary necrosis.
- Both patients had a history of severe COVID-19 within the past year and were on immunosuppressive therapy.
- They were treated with double J stenting and fluconazole for the fungal infection.
Findings:
- One patient achieved a complete recovery.
- The other patient, who had pre-existing chronic kidney disease stage 4, progressed to dialysis-dependent renal failure after a subsequent bacterial sepsis episode.
Implications:
- The increased incidence of candida-associated renal papillary necrosis may be linked to the immunomodulatory effects of severe COVID-19.
- Immunosuppressive treatments, potentially in combination with COVID-19's effects, could contribute to the development of this rare renal complication.
- This suggests a need for heightened awareness and monitoring of renal function in post-COVID-19 patients on immunosuppressants.
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