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Rt-PA-assisted Vitreoretinal Surgery for Open Globe Injury with Suprachoroidal Hemorrhage: Outcomes and Predictive
Tingkun Shi1, Yuqiang Huang, Honghe Xia
1Joint Shantou International Eye Center, Shantou University & the Chinese University of Hong Kong, Shantou, China, 515041.
Retina (Philadelphia, Pa.)
|March 3, 2025
Summary
Recombinant tissue plasminogen activator (rt-PA)-assisted vitreoretinal surgery effectively restores vision and ocular structure in open globe injuries with suprachoroidal hemorrhage. Retinal loss is a key predictor of poor visual and anatomical outcomes.
Area of Science:
- Ophthalmology
- Surgical Innovation
- Trauma Care
Background:
- Open globe injury (OGI) with suprachoroidal hemorrhage (SCH) presents significant challenges in restoring visual function.
- Effective management strategies are crucial for improving outcomes in severe ocular trauma.
Purpose of the Study:
- To evaluate the visual and anatomical results of rt-PA-assisted vitreoretinal surgery for OGI with SCH.
- To identify prognostic factors influencing visual outcomes and retinal attachment.
Main Methods:
- Retrospective analysis of 94 eyes undergoing rt-PA injection, suprachoroidal drainage, and vitreoretinal surgery.
- Multivariate regression analysis to determine predictors of visual acuity and retinal detachment.
Main Results:
- Successful SCH drainage in 80.9% of eyes.
- Significant improvement in visual acuity (better than counting fingers) from 4.26% to 48.94%.
- Retinal attachment rates of 84.04% at 3 months and 77.66% at last follow-up.
- Retinal loss identified as a strong predictor of poor visual and anatomical outcomes.
Conclusions:
- rt-PA-assisted vitreoretinal surgery offers an efficient approach for managing OGI with SCH.
- Early intervention and surgical techniques are vital for preserving ocular structure and function.
- Identifying and addressing retinal loss is critical for optimizing patient prognosis.
