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    Area of Science:

    • Medical Imaging
    • Machine Learning
    • Computer Vision

    Background:

    • Multi-task learning (MTL) is established in natural image analysis but underexplored in medical imaging.
    • Existing MTL methods often treat tasks as competing objectives, limiting performance.
    • This research addresses the need for improved MTL strategies in the medical domain.

    Purpose of the Study:

    • To propose a novel multi-level optimization approach for MTL in medical imaging.
    • To foster a cooperative learning environment where tasks benefit each other.
    • To develop robust sub-models resilient to variations in other tasks.

    Main Methods:

    • Formulated MTL as a multi-level optimization problem, unlike traditional multi-objective formulations.
    • Advocated for a cooperative strategy enabling tasks to leverage features from one another.
    • Introduced a novel optimization strategy to find flat minima for robust sub-model learning.

    Main Results:

    • Demonstrated advantages on the OrganCMNIST dataset through parameter and comparison studies.
    • Validated efficacy on three eye-related medical image datasets.
    • Showcased superior performance compared to state-of-the-art MTL approaches.

    Conclusions:

    • The proposed multi-level optimization significantly enhances MTL performance in medical imaging.
    • The cooperative approach leads to more robust and versatile multi-purpose models.
    • This work opens new avenues for MTL applications in medical image analysis.