Real-Time Epileptic Seizure Prediction Method With Spatio-Temporal Information Transfer Learning

Despite numerous studies aimed at improving accuracy, the accurate prediction of epileptic seizures remains a challenge in clinical practice due to the high computational cost, poor real-time performance, and over-reliance on labelled data. To address these issues, a real-time seizure prediction method with spatio-temporal information transfer learning (RTSPM-STITL) has been proposed in this study. In the RTSPM-STITL method, the human brain is regarded as a time-varying high-dimensional neurodynamic system, in which epileptic seizures are viewed as state transitions caused by time-varying system parameters. Specifically, the spatio-temporal information transfer (STIT) model is firstly constructed by the recurrent neural network (RNN) and trained by the Force Learning (a real-time learning mechanism). Then the STIT model is utilized to transform the high-dimensional neurodynamic data into low-dimensional time series to capture the dynamic features of epileptic seizures. Also, the critical slowing down effect (CSD) of seizure dynamics is used to detect warning signals. The experimental results demonstrate that the proposed method can achieve higher accuracy and sensitivity without labeled data on both the CHB-MIT and Siena scalp EEG databases. Especially, the parameters of the STIT model can be updated in real-time based on patient data, without iterative training. More importantly, the STIT model can maintain high sensitivity and accuracy with only 48400 parameters, which is reduced by more than 91% compared with contrast models in this experiment. Therefore, the proposed method can significantly reduce the computational cost and accurately predict epileptic seizures, as well as with high real-time, practicality, applicability, and interpretability.