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The Blood-brain Barrier

The Blood-brain Barrier

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Related Experiment Video

Updated: May 24, 2025

Evaluation of Blood-Brain Barrier Breakdown in a Mouse Model of Mild Traumatic Brain Injury

Evaluation of Blood-Brain Barrier Breakdown in a Mouse Model of Mild Traumatic Brain Injury

Published on: October 18, 2024

Thermal Threshold for Localized Blood-Brain Barrier Disruption.

Sebastien Bar, Oliver Buchholz, Christian Munkel

IEEE Transactions on Bio-Medical Engineering

|March 3, 2025

Summary

This summary is machine-generated.

Mild hyperthermia can open the Blood-Brain Barrier (BBB), enhancing drug delivery for neurological diseases. Precise temperature monitoring ensures controlled BBB permeability for targeted brain therapies.

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Last Updated: May 24, 2025

Evaluation of Blood-Brain Barrier Breakdown in a Mouse Model of Mild Traumatic Brain Injury

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Published on: October 18, 2024

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Published on: November 30, 2012

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

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Published on: May 4, 2015

Area of Science:

Neuroscience
Biomedical Engineering
Pharmacology

Background:

The Blood-Brain Barrier (BBB) protects the central nervous system but hinders neurological disease treatment.
Altering BBB permeability can increase localized drug concentrations for enhanced therapeutic effects.

Purpose of the Study:

To investigate Blood-Brain Barrier (BBB) permeability alteration using localized mild temperature increases.
To address challenges in accurately determining and monitoring thermal dosages during hyperthermia treatments.

Main Methods:

Utilized an infrared laser for localized, minimal thermal dose application in rats.
Employed noninvasive techniques like dynamic contrast enhancement-magnetic resonance imaging (DCE-MRI) and magnetic resonance thermometry (MRT) for monitoring.
Verified BBB disruption post-mortem using Evan's Blue dye.

Main Results:

A localized brain temperature increase of approximately 6 K (to 43°C) effectively disrupted the BBB.
In-vivo findings were consistent with post-mortem Evan's Blue extravasation results.

Conclusions:

BBB permeability can be altered and controlled with minimal, localized thermal doses, improving brain drug delivery.
Noninvasive imaging techniques (DCE-MRI, MRT) enable precise monitoring of temperature changes for controlled BBB disruption.