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Comprehensive analysis of the role of Caspases in glioma

Heming Wang1, Qunfang Mei2, Pengying Mei2

  • 1Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresource, Hainan University, Haikou 570228, China.

Brain Research
|March 3, 2025
PubMed

Insights

Caspase family genes (CASP1-10) are upregulated in glioma and linked to poor prognosis, especially in lower-grade glioma (LGG). These genes may serve as therapeutic targets for glioma treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Bioinformatics

Background:

  • Caspases (CASPs) are crucial in apoptosis and are implicated in various cancers.
  • While individual CASP genes have been studied in glioma, a comprehensive analysis of the entire CASP family's role is lacking.
  • Glioma prognosis and treatment strategies could benefit from understanding the CASP family's collective impact.

Purpose of the Study:

  • To comprehensively investigate the expression, prognostic value, and functional roles of the CASP family (CASP1-10) in glioma using bioinformatics.
  • To explore the potential of CASP family genes as therapeutic targets, particularly in lower-grade glioma (LGG).

Main Methods:

  • Bioinformatic analysis of CASP1-10 gene expression and its correlation with clinical parameters in glioma datasets.
  • Survival analysis (overall survival, recurrence-free survival, disease-specific survival, progression-free interval) was performed.
  • Investigation of the association between CASP family genes, immune infiltration, and cancer-related pathways.

Main Results:

  • CASP1-10 expression was significantly upregulated in glioma, including LGG and glioblastoma (GBM), and varied across clinical subgroups and cell types.
  • Most CASP1-10 members were associated with poor prognosis (overall survival, recurrence) in glioma and LGG, but not consistently in GBM.
  • CASP1-10 genes were identified as independent prognostic factors and showed diagnostic value, implicating them in immune infiltration and programmed cell death.

Conclusions:

  • The CASP family (CASP1-10) plays a significant role in glioma progression and prognosis, particularly in LGG.
  • CASP1-10 genes represent potential therapeutic targets for glioma, with natural caspase inhibitors like p35 showing promise, especially for LGG.
  • Further research into CASP family's role in immune modulation and apoptosis could refine glioma treatment strategies.
Keywords:
CASPsCancer-related pathwaysGliomaImmune infiltrationPrognostic factorsProgrammed cell death

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