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Updated: May 24, 2025
Quantifying the Antifungal Activity of Peptides Against Candida albicans
Published on: January 13, 2023
Three new antifungal phthalide derivatives from Cajanus cajan
Liyuan Yao1, Aikebaier Jumai1, Xiancai Li1
1Program for Natural Product Chemical Biology, State Key Laboratory of Plant Diversity and Specialty Crops & Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China; South China National Botanical Garden, Guangzhou 510650, PR China.
Abstract:
Three new phthalide derivatives, denominated Cajanthalides A, B and C (1-3), were identified from the leaves of Cajanus cajan. Their structures were meticulously elucidated through comprehensive analysis utilizing UV, IR, NMR (1D and 2D), HRESIMS, chiral analysis and DP4+ analysis. Notably, these new phthalide derivatives are present in racemic forms, with compounds 2 and 3 sharing identical planar structures. A plausible biogenetic pathway is proposed to account for the biosynthesis of compounds 1-3. Biological evaluation revealed that compound 2 exhibited moderate antifungal activity against C. neoformans, C. albicans and M. furfur with MIC values of 40 μg/mL.
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