Three new antifungal phthalide derivatives from Cajanus cajan
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Liyuan Yao1, Aikebaier Jumai1, Xiancai Li1
1Program for Natural Product Chemical Biology, State Key Laboratory of Plant Diversity and Specialty Crops & Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China; South China National Botanical Garden, Guangzhou 510650, PR China.
Abstract:
Three new phthalide derivatives, denominated Cajanthalides A, B and C (1-3), were identified from the leaves of Cajanus cajan. Their structures were meticulously elucidated through comprehensive analysis utilizing UV, IR, NMR (1D and 2D), HRESIMS, chiral analysis and DP4+ analysis. Notably, these new phthalide derivatives are present in racemic forms, with compounds 2 and 3 sharing identical planar structures. A plausible biogenetic pathway is proposed to account for the biosynthesis of compounds 1-3. Biological evaluation revealed that compound 2 exhibited moderate antifungal activity against C. neoformans, C. albicans and M. furfur with MIC values of 40 μg/mL.
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