Functions and Therapeutic Potentials of Long Noncoding RNA in Skeletal Muscle Atrophy and Dystrophy

Area of Science:

• Biochemistry
• Molecular Biology
• Genetics

Background:

• Skeletal muscle mass is regulated by protein synthesis and degradation.
• Muscle atrophy and muscular dystrophy involve complex molecular changes.
• Various signaling pathways and genetic factors contribute to muscle wasting.

Purpose of the Study:

• To review known long noncoding RNAs (lncRNAs) involved in muscle atrophy and muscular dystrophy.
• To elucidate the molecular mechanisms of these lncRNAs.
• To explore their therapeutic potential.

Main Methods:

• Literature review of studies on lncRNAs in muscle atrophy and dystrophy.
• Analysis of transcriptomic, translational, and epigenetic regulation.
• Investigation of signaling pathways impacting muscle homeostasis.

Main Results:

• Abnormal lncRNA expression is observed in atrophic and dystrophic muscles.
• lncRNAs regulate muscle protein balance and dystrophin expression.
• Specific lncRNAs are linked to denervation, aging, weightlessness, cachexia, and myogenesis disorders.

Conclusions:

• lncRNAs are critical in muscle atrophy and muscular dystrophy.
• Dysregulated lncRNAs represent promising therapeutic targets.
• Further research into lncRNA discovery and clinical application is warranted.