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Ketogenic diet and microRNAs: focus on cognitive function.

Diana Marisol Abrego-Guandique1, Erika Cione2,3, Maria Cristina Caroleo1,3

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Summary

The ketogenic diet (KD) may improve cognitive function by modulating microRNAs (miRNAs), which are linked to neurodegenerative diseases like Alzheimer's. This review explores the KD's role in enhancing cognition and the protective effects of miRNAs.

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biomarkercognitive functionketogenic dietketone bodiesmicroRNAs

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Dietary Science

Background:

  • Cognition relies on memory and is influenced by microRNAs (miRNAs).
  • MicroRNAs are implicated in neurodevelopment and cognitive function.
  • Dysregulated miRNAs are observed in neurodegenerative conditions affecting cognition.

Purpose of the Study:

  • To review the function of miRNAs in neurodevelopment and cognition.
  • To explore the impact of the ketogenic diet (KD) on cognitive function in humans.
  • To highlight the neuroprotective role of miRNAs in neurological disorders.

Main Methods:

  • Literature review of studies on ketogenic diet, miRNAs, and cognition.
  • Analysis of human and animal models investigating KD effects.
  • Synthesis of current research on miRNA modulation by KD.

Main Results:

  • Accumulating evidence suggests KD benefits neurodegenerative diseases impacting cognition.
  • KD has the potential to modulate miRNAs in the brain.
  • miRNAs play a critical role in maintaining cognitive health.

Conclusions:

  • The ketogenic diet shows promise for enhancing cognitive function.
  • MicroRNAs are key regulators of cognitive processes and neurological health.
  • Further research into KD and miRNA interactions could yield therapeutic strategies for cognitive decline.