Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Exercise and Muscle Performance01:27

Exercise and Muscle Performance

Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Muscle Stimulation Frequency01:22

Muscle Stimulation Frequency

The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
Isotonic and Isometric Muscle Contractions01:22

Isotonic and Isometric Muscle Contractions

Two primary types of muscle contractions are isotonic and isometric, each serving unique functions and involving distinct mechanisms. Both isotonic and isometric contractions are integral to the body's complex system of movement and stability. Isotonic exercises contribute significantly to functional strength and movement, while isometric contractions are crucial for maintaining posture and joint stability.
Isotonic contractions
Isotonic contractions occur when a muscle changes length while the...
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs01:15

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...
Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of High-Intensity Interval Training with Blood Flow Restriction Versus Normobaric Hypoxia on Physiological Parameters in Apparently Healthy Young Men.

Sports (Basel, Switzerland)·2026
Same author

Impact of Resistance Training on Body Composition, Physical Fitness, and Cardiometabolic Health in Children and Adolescents With Overweight/Obesity: An Umbrella Review With Meta-Analyses.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2026
Same author

Neuromuscular Activation Patterns in Response to Windlass Stimulation and Biofeedback: A Surface EMG Study.

Sports (Basel, Switzerland)·2026
Same author

Comparison of two nutritional protocols in body re-composition of resistance-trained participants.

European journal of applied physiology·2026
Same author

Relationship Between Kinesiophobia and Biomechanical, Postural, and Neuromuscular Parameters of the Lower Limbs: A Systematic Review.

Sports health·2026
Same author

Comparing Acute Effects of Caffeine Delivery Forms on Cross-Training Performance: A Randomized Placebo-Controlled Crossover Trial.

Nutrients·2026

Related Experiment Video

Updated: Jun 25, 2026

A Simple and Inexpensive Running Wheel Model for Progressive Resistance Training in Mice
06:59

A Simple and Inexpensive Running Wheel Model for Progressive Resistance Training in Mice

Published on: April 28, 2022

Comparison of Repetition-Based Progressive-Overload Strategies in Resistance Training: Rest-Pause Versus Drop Sets.

Salvador Vargas-Molina1,2, Alejandro García-Palumbo3, Jorge L Petro2,4

  • 1Physical Education and Sport Area, Faculty of Medicine, University of Málaga, Málaga, Spain.

Scandinavian Journal of Medicine & Science in Sports
|June 24, 2026
PubMed
Summary

Progressive overload rest-pause (PO-RP) and progressive overload drop-set (PO-DS) training yield similar results in body composition and strength for resistance-trained adults. Both methods effectively increase lean mass and maximal strength without significant differences between them.

Keywords:
body compositionexercise traininghypertrophymuscle strengthphysical fitness

More Related Videos

Versatility of Protocols for Resistance Training and Assessment Using Static and Dynamic Ladders in Animal Models
08:31

Versatility of Protocols for Resistance Training and Assessment Using Static and Dynamic Ladders in Animal Models

Published on: December 17, 2021

Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage
07:29

Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage

Published on: August 31, 2022

Related Experiment Videos

Last Updated: Jun 25, 2026

A Simple and Inexpensive Running Wheel Model for Progressive Resistance Training in Mice
06:59

A Simple and Inexpensive Running Wheel Model for Progressive Resistance Training in Mice

Published on: April 28, 2022

Versatility of Protocols for Resistance Training and Assessment Using Static and Dynamic Ladders in Animal Models
08:31

Versatility of Protocols for Resistance Training and Assessment Using Static and Dynamic Ladders in Animal Models

Published on: December 17, 2021

Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage
07:29

Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage

Published on: August 31, 2022

Area of Science:

  • Exercise Physiology
  • Sports Science
  • Resistance Training

Background:

  • Rest-pause (RP) and drop sets (DS) are common resistance training intensification strategies.
  • Their effectiveness within a progressive overload (PO) model and under supervision requires further investigation.

Purpose of the Study:

  • To compare the effects of progressive overload rest-pause (PO-RP) and progressive overload drop-set (PO-DS) training on body composition and maximal strength.
  • To assess adaptations in resistance-trained adults under supervised conditions.

Main Methods:

  • Twenty-three resistance-trained adults were randomized to either PO-RP or PO-DS training groups.
  • Both groups trained twice weekly for 8 weeks under supervision with a standardized nutritional protocol.
  • Body composition was assessed via DXA, and maximal strength was measured using the one-repetition maximum (1-RM) bench press.

Main Results:

  • Both PO-RP and PO-DS led to significant increases in lean soft tissue mass and bench press 1-RM.
  • Adiposity-related outcomes (fat mass) remained unchanged in both groups.
  • No statistically significant differences in adaptations were observed between the PO-RP and PO-DS protocols.

Conclusions:

  • Supervised PO-RP and PO-DS training protocols result in comparable improvements in lean mass and maximal strength in resistance-trained adults.
  • Neither protocol significantly altered adiposity-related outcomes.
  • Further research is warranted to explore long-term effects and responses in diverse populations.