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Updated: May 24, 2025
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Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke
Published on: February 10, 2023
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Blood pressure management in reperfused ischemic stroke
Lucia B Varela1,2, Samanta Díaz Menai1, Camila Micaela Escobar Liquitay1
1Research Department, Instituto Universitario Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
The Cochrane Database of Systematic Reviews
|March 4, 2025
Summary
This review assesses intensive versus conventional blood pressure management after stroke reperfusion. It aims to determine if lowering systolic blood pressure (target <160 mmHg) improves outcomes compared to a higher target (<180 mmHg).
Area of Science:
- Neuroscience
- Cardiology
- Clinical Trials
Background:
- Stroke is a leading cause of disability and death.
- Reperfusion therapies like thrombolysis and thrombectomy are crucial for acute ischemic stroke.
- Blood pressure management is a key factor in stroke recovery and secondary prevention.
Purpose of the Study:
- To evaluate the benefits and harms of intensive systolic blood pressure management (target <160 mmHg) versus conventional management (target <180 mmHg).
- To assess outcomes in patients undergoing ischemic stroke reperfusion.
- To inform clinical guidelines for post-stroke blood pressure control.
Main Methods:
- This is a protocol for a Cochrane Review.
- The review will synthesize evidence from relevant randomized controlled trials.
- Systematic search strategies will be employed to identify eligible studies.
Main Results:
- Results are pending the completion of the systematic review.
- The review will analyze data on clinical outcomes, safety, and adverse events.
- Specific findings will be reported upon data synthesis.
Conclusions:
- Conclusions will be drawn based on the synthesized evidence from the review.
- The findings will guide clinical decision-making regarding blood pressure targets after reperfusion therapy for ischemic stroke.
- Recommendations for future research may be provided.
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