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DNA Sensing with Whispering Gallery Mode Microlasers.
Soraya Caixeiro1,2, Robert Dörrenhaus3, Anna Popczyk1
1Department of Chemistry and Biochemistry, Humboldt Centre for Nano- and Biophotonics, Institute for Light and Matter, Greinstrasse 4-6, 50939 Cologne, Germany.
Nano Letters
|March 4, 2025
Summary
This study introduces a novel DNA-based sensor using whispering gallery mode (WGM) microlasers for real-time nucleic acid detection. The platform enhances sensitivity with gold nanoparticles and offers potential for diagnostics and drug delivery.
Area of Science:
- Biotechnology
- Nanotechnology
- Biosensing
Background:
- Nucleic acid sensing is vital for diagnostics and molecular research.
- Precise identification of DNA and RNA interactions is key.
Purpose of the Study:
- To develop an innovative sensing platform for real-time nucleic acid detection.
- To enhance sensitivity and explore applications in diagnostics and drug delivery.
Main Methods:
- Utilized DNA-functionalized whispering gallery mode (WGM) microlasers.
- Correlated spectral shifts to refractive index changes for detection.
- Incorporated gold nanoparticles and hairpin structures to enhance sensitivity and functionality.
Main Results:
- Demonstrated real-time detection of DNA hybridization and structural changes.
- Achieved enhanced sensitivity using gold nanoparticles and specific labeling strategies.
- Showcased ionic strength influence on DNA compactness and a hairpin system for controlled release.
Conclusions:
- The WGM-based platform provides a versatile tool for sequence-specific nucleic acid sensing.
- The system shows promise for multiplexed detection and in vivo applications.
- Potential applications include advanced diagnostics, therapeutic monitoring, and cellular research.
