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Updated: May 5, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Multi-responsive Pickering emulsions stabilized by amphiphilic cellulose nanocrystals for building smart release
Keran Li1, Lifei Peng2, Jing Li2
1College of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu 610500, PR China; State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610500, PR China.
Abstract:
In this study, cellulose nanocrystals (CNC) were first extracted from peanut shells. Then, the monomers DMAEMA and MAA were grafted on the surface of CNC using reversible addition-fragmentation chain transfer (RAFT) polymerization to prepare multi-stimuli responsive nanoparticles (CNC/PDM), and they were used to stabilize Pickering emulsions. The effects of such factors as pH, nanoparticle concentration, water-to-oil ratio, and oil polarity on the stability of Pickering emulsions were investigated in detail. Pickering emulsions showed good smart response properties in pH, temperature and CO2 environmental stimuli. At the same time, the emulsifier showed excellent stability in various real oil phases, which had a wide range of practical applications. In addition, curcumin was encapsulated in the oil phase of the emulsions and the encapsulation efficiency (EE) was determined to be higher than 80 %. Simulated in vitro digestion experiments revealed that both the release of free fatty acids and the bioaccessibility of curcumin in curcumin-loaded emulsions were dramatically improved (bioaccessibility increased by about 4.3 times). Consequently, the present study provided an effective strategy for the preparation of multi-responsive Pickering emulsions, which offered new perspectives for improving the bioavailability of fat-soluble drugs.
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