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  3. Antigen-presenting Cancer Associated Fibroblasts Enhance Antitumor Immunity And Predict Immunotherapy Response.
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  3. Antigen-presenting Cancer Associated Fibroblasts Enhance Antitumor Immunity And Predict Immunotherapy Response.

Related Experiment Video

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
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Antigen-presenting cancer associated fibroblasts enhance antitumor immunity and predict immunotherapy response.

Junquan Song1,2, Rongyuan Wei1,2, Chenchen Liu1,2

  • 1Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.

Nature Communications
|March 4, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Antigen-presenting cancer-associated fibroblasts (apCAFs) boost T cell immunity in gastric cancer. These apCAFs may predict immunotherapy response across multiple cancer types.

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Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • Cancer-associated fibroblasts (CAFs) are key players in tumor progression and immune modulation.
  • The functional diversity within CAFs is not fully understood, particularly in gastric cancer (GC).

Purpose of the Study:

  • To identify and characterize distinct CAF subsets in gastric cancer.
  • To investigate the role of antigen-presenting CAFs (apCAFs) in anti-tumor immunity.
  • To explore the potential of apCAFs as biomarkers for immunotherapy response.

Main Methods:

  • Identification of apCAFs based on high MHC II expression in GC tumors.
  • In vivo and in vitro experiments to assess apCAF function on T cells and macrophages.
  • Analysis of apCAF infiltration in tumors from immunotherapy responders across different cancer types.

Main Results:

  • Antigen-presenting CAFs (apCAFs) were identified in GC, predominantly near tertiary lymphoid structures.
  • apCAFs enhance T cell activation, proliferation, and cytotoxic capacity, bolstering anti-tumor immunity.
  • apCAFs promote pro-inflammatory macrophage polarization, creating a positive feedback loop that amplifies immune responses.
  • Higher apCAF infiltration correlates with immunotherapy response in various cancers.

Conclusions:

  • This study elucidates CAF heterogeneity in GC, identifying apCAFs as crucial immune modulators.
  • apCAFs represent a promising pan-cancer biomarker for predicting immunotherapy efficacy.
  • Targeting apCAFs could be a therapeutic strategy to enhance anti-tumor immunity.