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Updated: May 24, 2025
Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates
Published on: February 17, 2023
Extended-spectrum β-lactamase-producing Enterobacterales infections among infants following vertical colonization in
Mimori Abe1, Yuto Otsubo2, Tomoyuki Tame3
1Division of General Pediatrics, Department of Pediatrics, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan. mimoriabe@gmail.com.
Objective:
Extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) has become prevalent among neonates. The present study aimed to describe the incidence of ESBL-E colonization among neonates admitted to a NICU and the incidence of subsequent ESBL-E infection among those with ESBL-E colonization.
Study Design:
Patients admitted to the NICU at Tokyo Metropolitan Children's Medical Center between April 2011 and March 2023 were enrolled. On admission, the subjects were routinely screened for ESBL-E using pharyngeal and rectal swabs, and those colonized with ESBL-E were assessed for the development of an invasive ESBL-E infection during their NICU stay.
Results:
ESBL-E was isolated in 105 of the 8247 neonates (1.3%) admitted to the NICU. Among these patients, 12 (11.4%) experienced the development of an invasive ESBL-E infection.
Conclusion:
Although ESBL-E colonization occurred in only 1.3% of the neonates admitted to the NICU, 11.4% of them experienced the development of an ESBL-E infection.
