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Updated: Aug 16, 2026

Human Internal Mammary Artery IMA Transplantation and Stenting: A Human Model to Study the Development of In-Stent Restenosis
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Human Internal Mammary Artery IMA Transplantation and Stenting: A Human Model to Study the Development of In-Stent Restenosis

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In Silico Scenario of Bare Metal Stent and Drug-Eluting Stent Performance modeling in Patient-Specific Arteries: A

Georgia S Karanasiou, Vasileios S Loukas, Nikolaos S Tachos

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |March 5, 2025
    PubMed

    Insights

    This study used in silico modeling to compare Bare Metal Stents (BMS) and Drug-Eluting Stents (DES) in coronary arteries. Results show minor differences in performance, indicating stent coating insignificantly impacts deployment and stress outcomes.

    Area of Science:

    • Biomedical Engineering
    • Cardiovascular Research
    • Computational Modeling

    Background:

    • Atherosclerosis causes arterial plaque buildup, leading to heart attacks and strokes.
    • Drug-Eluting Stents (DES) and Bare Metal Stents (BMS) are used to treat arterial stenosis.
    • In silico modeling is crucial for predicting stent performance.

    Purpose of the Study:

    • To investigate the efficacy of BMS versus DES in a patient-specific coronary artery model.
    • To evaluate the impact of stent coating on arterial stress and deployment outcomes.
    • To compare the performance of different stent types using computational methods.

    Main Methods:

    • Utilized in silico modeling for a patient-specific coronary artery.
    • Compared two stent types: Bare Metal Stent (BMS) and Drug-Eluting Stent (DES).
    • Analyzed arterial stresses and von Mises stresses under different stent conditions.

    Main Results:

    • Most arterial stresses in both models were within the 0-0.5 MPa range.
    • Maximum von Mises arterial stresses were 0.20926 MPa (Model A) and 0.18103 MPa (Model B).
    • Peak stress was 719.86 MPa for BMS and 725.54 MPa for DES, showing minor differences.

    Conclusions:

    • Stent coating has an insignificant impact on deployment outcomes and scaffold stresses.
    • There were minor differences observed between the performance of BMS and DES.
    • In silico analysis suggests limited influence of stent coating on the studied parameters.

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