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Palatal canine impaction is not associated with third molar agenesis
Christianna I Papadopoulou1,2, Maria Athanasiou1, Nikolaos Gkantidis3
1Department of Orthodontics and Pediatric Dentistry, UZB-University School of Dental Medicine, University of Basel, Mattenstrasse 40, CH-4058 Basel, Switzerland.
European Journal of Orthodontics
|March 5, 2025
Summary
This study found no link between palatally impacted canines (PICs) and third molar agenesis. These common dental anomalies do not appear to share a common biological cause.
Area of Science:
- Dental genetics
- Developmental biology
- Oral health research
Background:
- Third molar agenesis and palatally impacted canines (PICs) are distinct dental anomalies.
- Previous reports suggested a potential shared genetic origin, but data remains inconsistent.
Purpose of the Study:
- To investigate the association between third molar agenesis and palatally impacted canines.
- To determine if these two dental phenotypes share a common biological mechanism.
Main Methods:
- A retrospective case-control study involving 310 individuals.
- Assessed the association between PICs and third molar agenesis using four regression models.
- Excluded individuals with other known genetic dental anomalies.
Main Results:
- No significant association was found between canine impaction and third molar agenesis in any regression model.
- Neither the severity nor patterns of PICs correlated with the severity or patterns of third molar agenesis (P > .05).
Conclusions:
- Palatal canine impaction is not associated with third molar agenesis when accounting for age, sex, and anomaly patterns.
- These findings suggest that PICs and third molar agenesis do not share a common biological basis.
