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Updated: May 24, 2025

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Linking Pathogenesis to Fall Risk in Multiple Sclerosis.

Jaylan Patel1, Marcel P Fraix1, Devendra K Agrawal1

  • 1Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, California 91766 USA.

Archives of Internal Medicine Research
|March 5, 2025
PubMed
Summary

Falls are a major concern for individuals with Multiple Sclerosis (MS) due to gait, cognitive, and fatigue issues. A comprehensive approach combining interventions and technology is crucial for fall prevention and improving quality of life.

Keywords:
CognitionFall riskFallsFatigueGaitMultiple sclerosis

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Area of Science:

  • Neurology
  • Rehabilitation Science
  • Gerontology

Background:

  • Multiple Sclerosis (MS) is a chronic neurological disorder leading to progressive disability.
  • Falls are a significant consequence of MS-related physical and cognitive impairments, impacting quality of life.
  • Fear of falling is a common psychological burden associated with MS.

Purpose of the Study:

  • To review major contributors to fall risk in individuals with MS.
  • To explore the implications of these factors, including fear of falling.
  • To discuss current and emerging interventions for fall prevention in MS.

Main Methods:

  • Literature review of studies on fall risk factors in Multiple Sclerosis.
  • Analysis of interventions including exercise, rehabilitation, cognitive-behavioral therapy, and self-management programs.
  • Exploration of disease-modifying therapies, emerging technologies, and machine learning for fall risk prediction.

Main Results:

  • Gait abnormalities, cognitive dysfunction, and fatigue are primary contributors to fall risk in MS.
  • These factors interact, causing mobility limitations and reduced quality of life.
  • Interventions show varied success; exercise, rehabilitation, and cognitive-behavioral therapy offer benefits, while disease-modifying therapies slow progression.

Conclusions:

  • A comprehensive, personalized strategy is needed for fall prevention in MS.
  • Interventions should target mobility, fall incidence, and quality of life.
  • Further research is essential to refine interventions and optimize long-term outcomes for individuals with MS.