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Enhancing Mesh-Tissue Integration in Menopausal Models Using a Platelet-Rich Plasma-Decellularized Amnion Scaffold
Alfa Putri Meutia1,2, Pribakti Budinurdjaja3, Amir Fauzi4
1Doctoral Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. a.meutia.urogyne@gmail.com.
International Urogynecology Journal
|March 5, 2025
Summary
Platelet-rich plasma-decellularized amnion scaffold (PRP-DAS) coating on surgical mesh reduced mesh contraction and inflammation. This PRP-DAS mesh enhanced tissue integration in a rabbit model, suggesting improved urogynecological surgery outcomes.
Area of Science:
- Biomaterials science
- Regenerative medicine
- Urogynecology
Background:
- Surgical mesh is used in urogynecology to support pelvic tissue but can cause complications like inflammation and mesh extrusion.
- Platelet-rich plasma-decellularized amnion scaffold (PRP-DAS) is a potential biomaterial to mitigate these complications.
Purpose of the Study:
- To evaluate the efficacy of a PRP-DAS coated mesh in improving mesh-tissue integration and reducing inflammatory response in a menopausal rabbit model.
Main Methods:
- Polypropylene mesh coated with PRP-DAS was implanted in menopausal rabbits (treatment group) and compared to uncoated mesh (control group).
- Mesh-tissue integration was assessed macroscopically, histologically, and immunohistochemically for inflammation, neovascularization, and collagen deposition over 90 days.
Main Results:
- No mesh extrusion occurred in either group. The PRP-DAS group showed significantly reduced mesh contraction.
- The PRP-DAS group exhibited lower inflammatory infiltrates and inflammatory markers (IL-17) on days 28 and 90.
- Significantly higher collagen deposition was observed in the PRP-DAS group by day 90, indicating enhanced tissue integration.
Conclusions:
- PRP-DAS coating on surgical mesh effectively reduces inflammatory response and enhances mesh-tissue integration.
- This biomaterial approach holds promise for improving outcomes in urogynecological mesh surgeries.
