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Urticarial vasculitis treated with colchicine.

J C Wiles, R C Hansen, P J Lynch

    Archives of Dermatology
    |June 1, 1985
    PubMed
    Summary
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    Colchicine effectively treated two patients with urticarial vasculitis when other therapies failed. This suggests colchicine may be a viable treatment option for this condition.

    Area of Science:

    • Dermatology
    • Rheumatology
    • Immunology

    Background:

    • Cutaneous vasculitis can manifest as an urticaria-like rash, sometimes linked to viral illnesses or autoimmune conditions like lupus or Sjögren's syndrome.
    • Urticarial vasculitis is frequently an immune complex-mediated disease, often occurring independently of other systemic diseases or infections.
    • Conventional treatments including antihistamines, prednisone, and immunosuppressants have shown variable success in managing urticarial vasculitis.

    Observation:

    • Colchicine has previously demonstrated efficacy in non-urticarial cutaneous vasculitis.
    • Two patients with refractory urticarial vasculitis, who had not responded to other treatments, were administered colchicine.
    • Both patients experienced a dramatic positive response to colchicine therapy.

    Findings:

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    • Colchicine treatment led to significant improvement in urticarial vasculitis symptoms in both studied patients.
    • The therapeutic success was observed even in cases where standard treatments were ineffective.
    • One patient maintained severe hypocomplementemia despite the clinical response to colchicine.

    Implications:

    • Colchicine represents a promising therapeutic option for patients suffering from urticarial vasculitis, particularly those with treatment-resistant disease.
    • Further investigation into colchicine's mechanism in urticarial vasculitis is warranted.
    • The persistent hypocomplementemia in one patient highlights the need for continued monitoring and potentially combination therapy.