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Plasma polyamines levels and post-stroke depression in ischemic stroke patients: A multicenter prospective study
Yu He1, Xinyue Chang1, Yi Liu1
1Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, Jiangsu Province, 215123, China.
High levels of plasma putrescine and spermidine are linked to an increased risk of post-stroke depression (PSD) in ischemic stroke patients. These polyamines may play a role in PSD development and could be potential therapeutic targets.
Area of Science:
- Neuroscience
- Biochemistry
- Clinical Medicine
Background:
- Polyamines are implicated in inflammation, ischemic stroke, and mental disorders.
- The specific association between polyamines and post-stroke depression (PSD) remains unclear.
- This study investigates plasma polyamine levels in relation to PSD risk.
Purpose of the Study:
- To prospectively examine the association between plasma putrescine, spermidine, and spermine levels and the risk of PSD.
- To determine if polyamine levels can improve the prediction of PSD in ischemic stroke patients.
Main Methods:
- A multicenter cohort study involving 635 ischemic stroke patients.
- Plasma polyamine levels (putrescine, spermidine, spermine) were measured at baseline.
- Depression was assessed using the Hamilton Depression Rating Scale at 3-month follow-up.
Main Results:
- Elevated plasma putrescine and spermidine levels were positively associated with increased PSD risk.
- The highest tertile of putrescine and spermidine showed significantly higher odds of PSD (ORs ≈ 1.77).
- Plasma putrescine and spermidine levels significantly improved PSD risk reclassification beyond established factors.
Conclusions:
- High plasma putrescine and spermidine levels are associated with a greater risk of PSD in ischemic stroke survivors.
- These polyamines are suggested to be involved in the pathophysiology of PSD.
- Plasma polyamines represent potential novel targets for PSD intervention.
