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Research progress on the bioactivity of compound polysaccharides: A review
1College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China.
Abstract:
Polysaccharides are an important biological response modifier. Due to their mild effects, low toxicity and small side effects, they are widely used. However, the pharmacological activity of compound polysaccharides (composed of two or more types of polysaccharides in a certain proportion) is stronger than that of single polysaccharides and has synergistic effects. Therefore, the research on compound polysaccharides is also increasing. This review systematically collated literature from four prominent databases-PubMed, Web of Science, Scopus, MDPI, and CNKI-up to 2024, encapsulating the current findings regarding the diverse biological activities of compound polysaccharides. Experimental investigations predominantly concentrate on immune activity, anti-tumor efficacy, modulation of gut microbiota, and antiviral activity. Among these areas, the synergistic effect of immune activity is particularly pronounced; however, research specifically addressing this phenomenon remains comparatively limited. Future research should continue to explore the ratio of compound polysaccharides and the factors affecting their biological activity through data sharing and multi-institutional cooperation. In addition, the synergistic effect of compound polysaccharides combined with other chemical components or drugs cannot be ignored.
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