Related Experiment Video

Updated: May 24, 2025

High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds
12:32

High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds

Published on: January 23, 2018

12.0K

TGR5 Activation by Dietary Bioactives and Related Improvement in Mitochondrial Function for Alleviating Diabetes and

Quanrun He1,2, Xinhang Li1,2, Haimeng Li1,2

  • 1School of Medicine, The Chinese University of Hong Kong, Shenzhen, 2001 Longxiang Boulevard, Longgang District, Shenzhen, Guangdong 518172, P.R. China.

Journal of Agricultural and Food Chemistry
|March 6, 2025
PubMed

Insights

Dietary compounds can activate Takeda G protein-coupled receptor 5 (TGR5) to help manage diabetes. This review explores how these natural bioactives and their mechanisms offer therapeutic potential for diabetes and its complications.

Area of Science:

  • Endocrinology and Metabolism
  • Nutritional Science
  • Pharmacology

Background:

  • Takeda G protein-coupled receptor 5 (TGR5), also known as GPBAR1, is a key regulator of glucose homeostasis and energy metabolism.
  • TGR5 activation is increasingly recognized for its therapeutic potential in managing diabetes and its associated complications.
  • Dietary bioactive compounds from functional foods and edible plants are emerging as natural activators of TGR5.

Purpose of the Study:

  • To comprehensively review the role of dietary bioactive compounds in activating TGR5 for diabetes management.
  • To analyze the mechanisms by which these compounds modulate TGR5 activity, including direct agonism and indirect pathways.
  • To consolidate scattered research on TGR5 activation by dietary bioactives for therapeutic applications in diabetes.

Main Methods:

  • Systematic literature review of studies investigating dietary bioactives and TGR5 activation.
  • Analysis of mechanisms of TGR5 activation, including direct receptor binding and indirect modulation.
  • Exploration of indirect pathways such as gut microbiota alterations and bile acid metabolism changes.

Main Results:

  • Dietary bioactive compounds demonstrate potential as TGR5 agonists, influencing glucose and energy metabolism.
  • Mechanisms involve both direct interaction with TGR5 and indirect modulation via the gut microbiome and bile acid pool.
  • Evidence suggests TGR5 activation by natural compounds may mitigate diabetic complications.

Conclusions:

  • Dietary bioactives represent a promising avenue for TGR5-targeted diabetes therapy.
  • Understanding the multifaceted mechanisms of TGR5 activation is crucial for developing effective interventions.
  • Further research into specific compounds and their clinical efficacy is warranted for diabetes management.
Keywords:
Bile acidsDiabetesDietary bioactivesGut microbiotaMitochondrial functionTGR5

More Related Videos

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides08:39

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides

Published on: September 16, 2020

7.9K
Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy08:47

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

Published on: December 7, 2017

9.6K

Related Concept Videos

Oral Hypoglycemic Agents: Biguanides and Glitazones01:26

Oral Hypoglycemic Agents: Biguanides and Glitazones

Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
149
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.1K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.3K
Hormones Regulating Blood Glucose01:16

Hormones Regulating Blood Glucose

Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
3.0K
Overview of Metabolism01:40

Overview of Metabolism

Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
29.4K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
222