Related Experiment Video

Updated: May 24, 2025

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

1.6K

Impact of comorbid burden on global left cardiac function and prediction models for myocardial function damage: a

XiaoFeng Qu1, Miaomiao Bai1, Jianbo Lyu1

  • 1Department of Radiology, The Second Hospital of Dalian Medical University, Dalian, China.

Frontiers in Medicine
|March 6, 2025
PubMed

Insights

Comorbid burden, even without organic heart disease, impairs cardiac function. This burden, along with sex and glucose levels, predicts heart damage, enabling early detection before ejection fraction drops.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Cardiovascular Disease

Background:

  • Comorbid conditions like hypertension, diabetes, and dyslipidemia are prevalent.
  • Assessing cardiac function in these patients is crucial, even without diagnosed heart disease.
  • Early detection of myocardial dysfunction is key to preventing adverse outcomes.

Purpose of the Study:

  • To investigate the impact of comorbid burden on myocardial function in patients without organic heart disease.
  • To develop predictive models for identifying myocardial function damage.
  • To assess the utility of cardiac magnetic resonance feature tracking (CMR-FT) in this population.

Main Methods:

  • Recruited 82 healthy individuals and 198 patients with comorbid burden (hypertension, T2DM, dyslipidemia).
  • Classified patients into groups based on the number of comorbidities (<2 and ≥2).
  • Utilized CMR-FT to measure left atrial (LA) and left ventricular (LV) myocardial strain parameters.

Main Results:

  • Patients with ≥2 comorbidities showed significantly reduced LA reservoir and conduit strain.
  • Both LV global longitudinal and radial strain decreased in patients with comorbid burden (<2 and ≥2).
  • LV global circumferential strain was reduced in the ≥2 comorbidity group. Comorbid burden, male sex, PBG, and FBG predicted LV damage (AUC=0.848).

Conclusions:

  • CMR-FT can detect subclinical myocardial damage in patients with comorbid burden before LVEF decline.
  • Comorbid burden, sex, and glucose levels are strong predictors of LV myocardial function damage.
  • Comorbid burden and male sex have predictive value for LA myocardial function damage.
Abstract

Keywords:
CMR-FTcomorbid burdendyslipidemiahypertensionmyocardial function damagemyocardial straintype 2 diabetes mellitus

More Related Videos

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking07:21

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Published on: February 12, 2011

14.3K
Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging11:13

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

Published on: May 24, 2021

6.2K

Related Concept Videos

Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.3K
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
499