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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

383
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
383
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

425
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Glaucoma: Overview01:25

Glaucoma: Overview

493
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
493

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[Features of daily patterns of blood flow parameters in the internal carotid arteries in primary open-angle glaucoma].

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Related Experiment Video

Updated: May 24, 2025

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
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[Neuroprotective therapy of glaucoma].

A S Vlasova1, S A Petrov1,2, E V Renzyak1,3

  • 1West Siberian Institute of Postgraduate Medical Education, Tyumen, Russia.

Vestnik Oftalmologii
|March 6, 2025
PubMed
Summary

Glaucoma is a neurodegenerative disease where high intraocular pressure (IOP) is a key factor. However, even with normalized IOP, glaucoma can progress, necessitating a review of its complex mechanisms and treatments.

Keywords:
antioxidantsethylmethylhydroxypyridine succinateglaucoma optic neuropathyneuroprotectionprimary open-angle glaucoma

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Pathophysiology

Background:

  • Glaucoma is a chronic, multifactorial neurodegenerative disease affecting optic nerves.
  • Elevated intraocular pressure (IOP) and its fluctuations are primary local risk factors for glaucoma progression.
  • Stabilization of the glaucomatous process is not always achieved even after normalizing IOP.

Purpose of the Study:

  • To review pathophysiological mechanisms of glaucomatous optic neuropathy development and progression.
  • To discuss current therapeutic management strategies for glaucoma.
  • To synthesize findings from international and Russian studies.

Main Methods:

  • Literature review of international and Russian studies.
  • Analysis of pathophysiological mechanisms.
  • Evaluation of current therapeutic approaches.

Main Results:

  • Elevated IOP and diurnal fluctuations are significant risk factors.
  • Glaucomatous process can advance despite normalized IOP.
  • Pathophysiology involves complex neurodegenerative mechanisms.

Conclusions:

  • Understanding complex pathophysiological mechanisms is crucial for glaucoma management.
  • Current therapeutic strategies require continuous evaluation and potential enhancement.
  • Further research into non-IOP-related factors is warranted.