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Associations between Blood DNA Methylation and Histopathological Features in Lupus Nephritis

Patrick Demkowicz1, Ieva Kavaliauskaite2, Sophia C Faulkner3

  • 1Yale School of Medicine, Yale University, New Haven, CT.

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Abstract

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
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