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Electrocardiographic abnormalities in chagasic patients compared to the general population: A systematic review with

Bruno Felipe Santos de Oliveira1, Cárita Victória Carvalho de Santana1, Luiz Filippe Vago Pereira1

  • 1Faculty of Medicine of Bahia, Federal University of Bahia, Bahia, Brazil.

Journal of Electrocardiology
|March 6, 2025
PubMed

Insights

Chagas disease (CD) significantly correlates with various electrocardiogram abnormalities, indicating a need for consistent patient monitoring. Early detection of these cardiac changes is crucial for timely interventions in Chagas disease management.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Chagas disease (CD) is a significant global health concern.
  • Chronic CD often progresses to chagasic cardiomyopathy, characterized by specific electrocardiogram (ECG) abnormalities.

Purpose of the Study:

  • To systematically review and meta-analyze the prevalence of cardiac arrhythmias in CD patients.
  • To determine the discriminative value of clinical and epidemiological variables for specific arrhythmias in CD.

Main Methods:

  • A comprehensive literature search was conducted in MEDLINE/PubMed, Embase, and Cochrane Library.
  • Meta-analyses were performed on data from 88 studies, including 322,608 participants, comparing ECG abnormalities in CD patients versus non-CD individuals.

Main Results:

  • A significant association was found between positive CD serology and single ECG changes (OR: 2.86).
  • Specific arrhythmias like bundle branch blocks, atrioventricular blocks, and atrial fibrillation showed significant associations with CD.
  • The discriminative capacity for single ECG alterations indicated a sensitivity of 0.511 and specificity of 0.622.

Conclusions:

  • The study confirms a strong link between Chagas disease and numerous electrocardiogram abnormalities.
  • Findings underscore the importance of continuous surveillance and targeted treatments for improving outcomes in chagasic cardiomyopathy.
Abstract

Keywords:
ArrhythmiaCardiomyopathyChagas diseaseElectrocardiogram

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