Pain sensitivity questionnaire in endometriosis.
Avonae J Gentles1, Sarah Wong1, Natasha L Orr2
1Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada; BC Women's Center for Pelvic Pain and Endometriosis Vancouver, BC, Canada.
The Journal of Pain
|March 6, 2025
Summary
The Pain Sensitivity Questionnaire Minor (PSQ-M) is not an optimal tool for assessing central sensitization in endometriosis patients. It showed weak correlations with pain sensitivity and quality of life, suggesting limitations in clinical application.
Area of Science:
- Pain research
- Gynecology
- Clinical assessment
Background:
- Nociplastic pain and central sensitization are increasingly recognized in endometriosis-associated pain.
- The Pain Sensitivity Questionnaire Minor (PSQ-M) assesses widespread pain sensitivity, but its utility in endometriosis central sensitization is understudied.
- The Central Sensitization Inventory (CSI) is a validated measure for central sensitization.
Purpose of the Study:
- To compare the PSQ-M with the CSI as a clinical proxy for central sensitization in individuals with endometriosis.
- To evaluate the association of PSQ-M with central sensitivity syndromes, comorbidities, and quality of life in endometriosis.
- To assess the impact of endometriosis surgery on PSQ-M and CSI scores.
Main Methods:
- Analysis of data from 983 endometriosis participants in a prospective registry (January 2020 - December 2022).
- Comparison of PSQ-M scores with CSI scores, number of central sensitivity syndromes, pelvic pain comorbidities, and quality-of-life measures.
- Assessment of PSQ-M and CSI changes before and after endometriosis surgery.
Main Results:
- A weak positive correlation was found between PSQ-M and CSI scores (r=0.099, p<0.001).
- PSQ-M showed weak correlations with central sensitivity syndromes and comorbidities (r=0.093, p<0.001), unlike CSI (r=0.687, p<0.05).
- PSQ-M scores were not significantly associated with baseline or post-operative quality-of-life; surgical treatment did not significantly alter PSQ-M scores.
Conclusions:
- The PSQ-M demonstrates weak correlations with central sensitization indicators and quality of life in endometriosis patients.
- The PSQ-M may not be the optimal clinical proxy for assessing central sensitization in endometriosis.
- Surgical intervention for endometriosis does not appear to directly resolve central sensitization as measured by PSQ-M.
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